![]() ![]() ![]() Curcuma species exhibit inter and intraspecific differences in the biologically active principles combined with morphological differences in the above-ground vegetative and floral characteristics and the under-ground rhizome characteristics ( Sasikumar, 2005). It is grown in tropical and subtropical areas of the world, extensively cultivated in Asian countries, viz., India, Burma, Bangladesh, China, Indonesia, Japan, Taiwan, Thailand, and Vietnam ( Chattopadhyay et al., 2004 Damalas, 2011). Curcuma domestica), Curcuma aromatica, and Curcuma xanthorrhiza are other common species ( Itokawa et al., 2008). Besides, the widespread Curcuma longa (syn. To date, over 100 known species are reported in the species of Curcuma ( Esatbeyoglu et al., 2012). Curcuma has developed by incessant cross-breeding and selection. We also discuss the research gap and future research directions needed to propose curcumin as a promising therapeutic candidate.Ĭurcuma longa commonly referred to as turmeric is an ancient perennial herb belonging to the family Zingiberaceae and native to India. In this review, we discuss the different curcumin nanoformulation and nanocurcumin implications for different therapeutic applications as well as the status of ongoing clinical trials and patents. However, most of the nanoformulation of curcumin remained at the concept level evidence, thus, several questions and challenges still exist to recommend the nanocurcumin as a promising candidate for therapeutic applications. So far, many curcumin nanoformulations have been developed to enhance curcumin delivery, thereby overcoming the low therapeutic effects. The two most popular and effective techniques are ionic gelation and antisolvent precipitation. ![]() For the synthesis of nanocurcumin, an array of techniques has been developed and each technique has its own advantages and individual characteristics. Research efforts so far and data from the available literature have shown a satisfactory potential of nanorange formulations of curcumin (Nanocurcumin), it increases all the biological and pharmacological benefits of curcumin, which was not significantly possible earlier. Hence, researchers have attempted to enhance the biological and pharmacological activity of curcumin and overcome its drawbacks by efficient delivery systems, particularly nanoencapsulation. However, its low water solubility, poor bioavailability, and rapid metabolism represent major drawbacks for its successful therapeutic applications. It has drawn immense attention in recent years for its variety of biological and pharmacological action. Curcumin (diferuloylmethane) is a hydrophobic bioactive ingredient found in a rhizome of the C. 3Faculty of Biotechnology, College of Applied Life Science, Sustainable Agriculture Research Institute (SARI) and Jeju International Animal Research Center (JIA), Jeju National University, Jeju, South KoreaĬurcuma longa is an important medicinal plant and a spice in Asia.2Department of Plant Molecular Biology and Bioinformatics, Center for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore, India.1Subtropical Horticulture Research Institute, Jeju National University, Jeju, South Korea.Adhimoolam Karthikeyan 1, Natesan Senthil 2 and Taesun Min 3* ![]()
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